– Clinical presentation of platelet disorders vs factor disorder. Epistaxis and petechiae are more suggestive of platelet disorders. Factor deficiency is usually associated with larger bleeds such as hemoarthrosis.

– Palpable purpura….think Leukocytoclastic Vasculitis.

– Thrombocytopenia Framework: Decreased production, increased breakdown, sequestration, dilutional

– Treatment for APL is ATRA. Remember to consider ATRA differentiation syndrome which can present with pleural effusions, edema, shortness of breath, and fever. Treat ATRA differentiation syndrome with Prednisone.

– Causes of MAHA: DIC, TTP/HUS, malignant hypertension, mechanical valves, HELLP/Pre-eclampsia, Scleroderma renal crisis

– It is important to distinguish between TTP and DIC because the treatment is different. DIC – treat the underlying cause and supportive care. TTP – treat with Plasmapharesis.

	TTP	DIC
Thrombocytopenia	x	x
Fibrin Degradation Products		x
Elevated D-Dimer		x
Low Fibrinogen		x
Elevated LDH	x	x
Elevated PT and PTT		x
MAHA/Schistocytes	x	x
ADAMTS13	x
Leukopenia		x