Teaching Pearls:

• Inherited Thrombotic Diseases
  • Factor V Leiden
    • Moderate risk of thrombosis
  • Prothrombin G2120A mutation
    • Moderate risk of thrombosis
  • Protein C Deficiency (higher risk of thrombosis)
  • Protein S deficiency (higher risk of thrombosis)
  • ATIII Deficiency (higher risk of thrombosis)
• Factor V Leiden is the most common inherited thrombotic disease
  • Occurs in 5% of Caucasians
  • Heterozygotes have 5-fold increase in thrombosis; double hit has 50-fold increase.
• Treatments for coagulation reversal
  • FFP
    • Plasma containing normal factors
    • May take 1-2 hours for action
    • Higher volume load
  • Kcentra
    • Concentrate with factors II, VII, IX, and X
    • Immediate
  • Vitamin K
    • Duration of action approximately 4-12 hours