Teaching Pearls:

• Common causes of palpable purpura (leukocytoclastic vasculitis)
  • Infections
    • HBV, HCV, HIV, etc
  • Medications
    • Commonly occurs 7-10 days after the initiation of a medications
    • Common culprit medications include penicillin, cephalosporin, NSAIDs, etc
  • Autoimmune disease (see below)
  • Malignancy
    • Paraneoplastic syndrome
• Autoimmune Disease with palpable purpura
  • Granulomatosis Polyangiitis (Wegeners)
    • Hepatorenal syndrome with sinusitis
    • c-ANCA/anti-Pr-3 positive
  • Churg Strauss Syndrome
    • Associated with eosinophilia
    • p-ANCA positive
  • Microscopic polyangittis
    • p-ANCA positive
  • Cyroglobulinemic vasculitis
    • HCV positive
    • cryoglobin positive
  • HSP
    • palpable purpura with abdominal pain, arthralgia, renal involvement
    • Skin biopsy positive for LCV with IgA deposits