Resident Report 4/4 – Thrombocytopenia

Teaching Pearls:

  • Categories of Thrombocytopenia
    • Underproduction
    • Over-destruction/consumption
    • Splenic Sequestration
      • ~About 1/3 of the platelets reside in the spleen. The larger the spleen, the higher percentage of platelets that stay in the spleen.
    • Pseudothrombocytopenia
  • Etiologies for Thombocytopenia + the following:
    • Fever
      • Infection, sepsis, DI
    • Hepatosplenomegaly
      • Liver disease, hypersplenism, lymphoma
    • Neuro findings
      • TTP/HUS, Vit B12 deficiency, Cu deficiency
    • Lymphadenopathy
      • Infection, lymphoma, malignancy
    • Thrombosis
      • HIT, APLS, PNH
    • No other findings
      • ITP, drug induced thrombocytopenia, HIV, HCV, MDS

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