We discussed a case about an elderly woman w/ recent hospitalization for pneumonia, who presented w/ acute watery diarrhea, fevers, and encephalopathy, found to be in septic shock due to fulminant C diff colitis.

Disease severity

Treatment (2021 IDSA Updated Guidelines)

• Updated IDSA guidelines recommend Fidaxomicin over Vancomycin in nonfulminant C diff infection. Can still treat with PO Vancomycin.
  • But fidaxomicin is $$$$, which can be a barrier
• For recurrent C diff infections: If prior C diff infection was w/in the last 6 months, treat with adjunctive Bezlotoxumab