We discussed a case of a young woman w/ refractory AML, who was admitted for relapse of AML and developed new acute edematous (“juicy”), violaceous plaques, found to have Sweet syndrome.

Types

• Idiopathic (classic)
• Malignancy-associated
• Drug-associated

Clinical manifestations

• Abrupt, painful, edematous (“juicy”), erythematous / violaceous
• Papules / plaques / nodules

Diagnosis

• Clinical assessment and diagnostic criteria (there are criteria for idiopathic and for drug-associated)
• Biopsy

Treatment

• Systemic glucocorticoids (1st line)