Elderly female with history of uncontrolled DM presenting with DKA and found to have a cavitary lung lesion found to have biopsy proving broad, aseptate, ribbon like hyphae consistent with mucormycosis. Mucormycosis is a invasive fungal infection (common species include Rhizopus, Mucor species); can cause necrosis of host tissue from invading vasculature. The main risk factor for developing mucormycosis: DM with DKA, steroids, underlying malignancy, AIDS and malnutrition. Most commo presentation of Mucor is rhino-orbital-cerebral mucor and pulmonary mucor. Treatment for our patient included lobectomy and Amphtericin IV prior and post surgery.
Differential for cavitary mass:
- Infection
- Lung abscess
- Mycobacteria
- S. Milleri
- S. Aureus
- S. Pyogenes
- Klebsiella
- Pseudomonas
- Tricuspid Endocarditis
- Lemierre Syndrome
- Cryptococcus
- Endemic Mycosis
- Molds- Mucormycosis
- Parasites-Paragonimiasis, Entamoeba
- Malignancy
- Squamous cell carcinoma
- Mets from GI/GU tumors
- Lymphoma, Kaposi Sarcoma
- Autoimmune
- GPA
- RA
- PE and infarcts