Morning Report 11/12/15 Autosomal Dominant Polycystic Kidney Disease

  • Autosomal Dominant Polycystic Kidney Disease
    • Type 1: ~85%, average age of developing ESRD is around 50yo
    • Type 2: ~15%, average age of developing ESRD is around 70yo
  • Cardiovascular disease is the most common cause of death in ADPKD and ADPKD is the most common inherited kidney disease
  • For an infected renal cyst, use a lipophilic antibiotic (for good cyst penetration) such as quinolones or bactrim
  • ADPKD is present in 5-10% of dialysis patients in the US
  • Renal manifestations include recurrent UTIs, cyst infection, hematuria from cyst hemorrhage, and nephrolithiasis (usually uric acid stones)
  • Extra-renal manifestations of ADPKD include diverticulosis, abdominal hernias, cysts in liver/thyroid/pancreas/seminal vesicles/etc, mitral valve prolapse, and cerebral aneurysms.
  • The biggest risk factor for cerebral aneurysms in patients with ADPKD is a family member with cerebral aneurysms
  • DDAVP for uremic platelets works by increasing vwF from endothelial cells

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