- Autosomal Dominant Polycystic Kidney Disease
- Type 1: ~85%, average age of developing ESRD is around 50yo
- Type 2: ~15%, average age of developing ESRD is around 70yo
- Cardiovascular disease is the most common cause of death in ADPKD and ADPKD is the most common inherited kidney disease
- For an infected renal cyst, use a lipophilic antibiotic (for good cyst penetration) such as quinolones or bactrim
- ADPKD is present in 5-10% of dialysis patients in the US
- Renal manifestations include recurrent UTIs, cyst infection, hematuria from cyst hemorrhage, and nephrolithiasis (usually uric acid stones)
- Extra-renal manifestations of ADPKD include diverticulosis, abdominal hernias, cysts in liver/thyroid/pancreas/seminal vesicles/etc, mitral valve prolapse, and cerebral aneurysms.
- The biggest risk factor for cerebral aneurysms in patients with ADPKD is a family member with cerebral aneurysms
- DDAVP for uremic platelets works by increasing vwF from endothelial cells
SCVMC IM Chief Resident Blog 