Type 1: ~85%, average age of developing ESRD is around 50yo
Type 2: ~15%, average age of developing ESRD is around 70yo
Cardiovascular disease is the most common cause of death in ADPKD and ADPKD is the most common inherited kidney disease
For an infected renal cyst, use a lipophilic antibiotic (for good cyst penetration) such as quinolones or bactrim
ADPKD is present in 5-10% of dialysis patients in the US
Renal manifestations include recurrent UTIs, cyst infection, hematuria from cyst hemorrhage, and nephrolithiasis (usually uric acid stones)
Extra-renal manifestations of ADPKD include diverticulosis, abdominal hernias, cysts in liver/thyroid/pancreas/seminal vesicles/etc, mitral valve prolapse, and cerebral aneurysms.
The biggest risk factor for cerebral aneurysms in patients with ADPKD is a family member with cerebral aneurysms
DDAVP for uremic platelets works by increasing vwF from endothelial cells
