DRESS SYNDROME- 07/06/16
Most commonly implicated drugs
1)Anti-seizure medications- Phenytoin, Carbamazepine, Lamotrigine etc.
Usually symptoms start 2-8 weeks after exposure (much later than SJS/TEN)
Fever, Malaise, Lymphadenopathy, Morbilliform eruption
Mucosal involvement less common than TEN/SJS
Facial edema in 50 % of cases
Leukocytosis with eosinophilia (usually >700 microL)
Increased LFT, proteinuria, and any organ system can be involved
Discontinue the offending drug!
Solumedrol 1 g/kg if organ involvement (evidence is limited)