AM Report 2/21/17: Chronic Myeloid Leukemia

Remember the breakdown and differentiation between AML, ALL, CML, CLL.  It starts with understanding the cell line formation:

cdr526538

Nice overview provided by Khan Academy: https://www.khanacademy.org/science/health-and-medicine/hematologic-system-diseases-2/leukemia/v/leukemia-classifications

Condition Epidemiology Clinical Signs/Symptoms CBC Morphology Translocations
Acute Lymphoblastic Leukemia (ALL) Childen (2-5 yo), male > female, association with Downs syndrome ↓ RBCs, ↓ PMNs, ↓ platelets, +HSM, bone pain, CNS manifestions, tumor lysis syndrome, mediastinal mass Anemia, thrombocytopenia, variable WBC (>25% lymphobasts) Condensed chromatin, scant cytoplasm, B cell – CD10+, Tdt+ t (12;21) kids – good prognosis; t(9;22) – poor prognosis
Chronic Lymphoblastic Leukemia (CLL) Adults Male >>> Female Asymptomatic or nonspecific, autoimmune hemolytic anemia Lymphocytosis >5000, low platelets, ↓ antibodies (hypogammaglobulinemia) Smudge cells, condensed chromatin, scant cytoplasm
Acute Myeloid Leukemia (AML) Adults > 60 yo (mean 67) Spontnaeous bleeding, petechiae, ecchymosis, DIC Anemia, thombocytopenia, >30% myeloblasts Auer rods, myeloblasts, monoblasts t (15;17) – APML – treat with ATRA
Chronic Myeloid Leukemia (CML) Ages 20-50; Rare in children Insidious onset, mild symptoms, splenomegaly Symptomatic WBC > 200k Hypercellular marrow t (9;22) – BCR-ABL – treat with TKI

970-174072 Smudge Cells (CLL)

auer-rod Auer Rods (AML)

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